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The Rogue Protein!!

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Swirl

I have always been intrigued by Disease and its Molecular underpinnings. Thanks to an explosion of technologies and branches of study we now know much more about disease and our response to them than we probably did a few centuries ago. The beauty, however, is that the more we unravel, the more twisted the problem seems to get. Just as we feel that we have begun to grasp the single unifying concept of an infectious agent, then along comes a startling new discovery and turns all our careful theories on their heads!!!

I have been longing to write on the current topic for a while now, and finally today I decided to take the plunge. So here goes, Prion Diseases. I am sure everyone has at least heard of prion diseases. Ok if not Prion, then at least the phrase “Mad Cow Disease” should definitely ring a bell. The unique aspect of this disease is very evident when one examines the extremely lucid definition of a prion given by the website MedicneNet.com, “A disease-causing agent that is neither bacterial nor fungal nor viral and contains no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions”.

The Deadly Prion.. The Rogue Protein

The Deadly Prion.. The Rogue Protein

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